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KMID : 0365819720120010281
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Journal of Pusan Medical College
1972 Volume.12 No. 1 p.281 ~ p.278
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The Cutaneous Response to the Mixture of Inflammatory Exudate and Serotonin in Rabbits
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Abstract
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This study was carried out to investigate the role of chemical madiators in the mechanism of inflammatory response. Various materials for test were prepared from an inflammatory exudate by some physicochemical methods. The exudate was obtained from the abdominal cavity of rabbit inflamed by croton oil. The inflammation-inducing effects of the materials, inflammatory exudate and its derivatives, alone and togother with serotonin were tested by injecting them into the abdominal dermis of normal rabbits. The cutaneous response to the materials injected was observed grossly at definite time intervals for 48 hours and some of the skin lesions were examined microscopically.
The results thus obtained were summarized as follows:
1. Both the exudate alone and the mixture of the exudate and serotonin had inflammation-inducing effect, but the effectiveness of the latter was more striking than the former.
2. The mzpr part of the effective substance was insoluble in chloroform, precipitated by acetone, and belonged to globulin fraction of the exudate.
3. The heat-labile substance of the exudate had inflammation-inducing effect for itself, but did have it under the coexistence of serotonin.
On the basis of the above, it was suggested that certain high molecular proteinaceous substance which is not injurious for itself but become injurious when mediated by serotonin or serotonin-like substances may take part in inflammtory response together with certain active substances which can produce inflammation for itself without any aid of chemical mediators.
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